Leser trélats tecken The Leser–Trélat sign is the explosive onset of multiple seborrheic keratoses (many pigmented skin lesions), often with an inflammatory base. This can be a sign of internal malignancy as part of a paraneoplastic syndrome. 1 acanthosis nigricans treatment 2 Leser-Trélat sign is the rapid onset of numerous seborrheic keratoses (benign, often pigmented skin lesions with a "stuck-on" appearance). 3 acanthosis nigricans bilder 4 The Leser-Trélat sign is the sudden development of multiple pruritic seborrheic keratoses, often associated with malignancy. 1–4 Roughly half of these associated malignancies are adenocarcinomas, most commonly of the stomach, breast, colon, or rectum. However, it can be seen in other malignancies, including lymphoma, leukemia, and squamous. 5 The Leser-Trélat sign is a dermatological paraneoplastic syndrome referring to the explosive and rapid eruption of multiple seborrheic keratoses. It is associated with a number of different cancers including adenocarcinoma (e.g. gastric, colorectal), breast cancer, and lymphoproliferative disorders. 6 Leser-Trélat Sign. Leser-Trélat sign is the rapid onset of numerous seborrheic keratoses (benign, often pigmented skin lesions with a "stuck-on" appearance). 7 mörka armhålor apoteket 8 Handflator får ett papilomatöst utseende som liknar den 'knottriga' strukturen som kan ses i magslemhinna. 9 Snabb uppkomst (veckor till ett par månader) av multipla SK, särskilt i kombination med synkron acanthosis nigricans, kallas för Leser-Trélat-tecken och kan. 10 The average age of onset of the sign of Leser-Trelat has been quoted to be approximately 61 years of age. There is no reported increased predilection amongst either sex or any race. Reports of the sign of Leser-Trelat in patients in the second decade of life in association with malignancy do increase the legitimacy of this sign as an accurate. 11